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KMID : 1141820210210030319
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Journal of Gastric Cancer
2021 Volume.21 No. 3 p.319 ~ p.324
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Successful Treatment of Advanced Gastric Cancer with Brain Metastases through an Abscopal Effect by Radiation and Immune Checkpoint Inhibitor Therapy
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Muto Momotaro
Nakata Hirotaka
Ishigaki Kenichi
Tachibana Shion
Yoshida Moe
Muto Mizue
Yanagawa Nobuyuki
Okumura Toshikatsu
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Abstract
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The abscopal effect refers to the phenomenon in which local radiotherapy is associated with the regression of metastatic cancer that is distantly located from the irradiated site. Here, we present a case of a patient with advanced gastric cancer and brain metastases who was successfully treated with brain radiotherapy and anti-programmed death-1 (PD-1) therapy-induced abscopal effect. Although anti-PD-1 therapy alone could not prevent disease progression, the metastatic lesions in the brain and also in the abdominal lymph node showed a drastic response after brain radiotherapy and anti-PD-1 therapy. To our knowledge, this is the first reported case of successful treatment of advanced gastric cancer with multiple brain and abdominal lymph node metastases, possibly through anti-PD-1 therapy combined with brain radiotherapy-induced abscopal effect. We suggest that the combination of brain radiotherapy and anti-PD-1 therapy may be considered as a therapeutic option for advanced gastric cancer, especially when there is brain metastasis.
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KEYWORD
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Gastric cancer, Abscopal effect, Immune checkpoint inhibitor, Brain metastasis, Radiation
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